Multiple Sclerosis is a debilitating chronic autoimmune disease of the central nervous system that results in lower quality of life. Medication adherence is important for reducing relapse, disease progression, and MS-related symptoms, particularly during the early stages of MS. However, adherence may be impacted by negative emotional states. Therefore, it is important to identify protective factors. Past research suggests that the ability to discriminate between negative emotional states, also known as negative emotion differentiation, may be protective against enactment of maladaptive (...) risk-related behaviors. However, less is known as to how NED may promote adaptive health behaviors such as medication adherence. Utilizing weekly diaries, we investigated whether NED moderates the association between negative affect and medication adherence rates across 58 weeks among patients newly diagnosed with MS. Results revealed that NED significantly moderated the relationship between negative affect and medication adherence. Specifically, greater negative affect was associated with lower adherence only for individuals reporting low NED. However, this link disappeared for those reporting moderate to high NED. Building upon past research, our findings suggest that NED may promote adaptive health behaviors and have important clinical implications for the treatment and management of chronic illness. (shrink)

Heterogeneity within MDD has hampered identification of biological markers (e.g., intermediate phenotypes, IPs) that might increase risk for the disorder or reflect closer links to the genes underlying the disease process. The newer characterizations of dimensions of MDD within Research Domain Criteria (RDoC) domains may align well with the goal of defining IPs. We compare a sample of 25 individuals with MDD compared to 29 age and education matched controls in multimodal assessment. The multimodal RDoC assessment included the primary IP (...) biomarker, positron emission tomography (PET) with a selective radiotracer for 5-HT1A ([11C]WAY-100635), as well as event-related functional MRI with a Go/No-go task targeting the Cognitive Control network, neuropsychological assessment of affective perception, negative memory bias and Cognitive Control domains. There was also an exploratory genetic analysis with the serotonin transporter (5-HTTLPR) and monamine oxidase A (MAO-A) genes. In regression analyses, lower 5-HT1A binding potential (BP) in the MDD group was related to diminished engagement of the Cognitive Control network, slowed resolution of interfering cognitive stimuli, one element of Cognitive Control. In contrast, higher/normative levels of 5-HT1A BP in MDD (only) was related to a substantial memory bias toward negative information, but intact resolution of interfering cognitive stimuli and greater engagement of Cognitive Control circuitry. The serotonin transporter risk allele was associated with lower 1a BP and the corresponding imaging and cognitive IPs in MDD. Lowered 5HT 1a BP was present in half of the MDD group relative to the control group. Lowered 5HT 1a BP may represent a subtype including decreased engagement of Cognitive Control network and impaired resolution of interfering cognitive stimuli. Future investigations might link lowered 1a BP to neurobiological pathways and markers, as well as probing subtype-specific treatment targets. (shrink)

A major shift has taken place since the 1960s concerning disclosure to patients that they have a diagnosis of cancer and that their disease is considered terminal. Full disclosure is now considered the patient's right in the United States. However, there remain many countries in which nondisclosure is still the norm. When patients from those countries are diagnosed with cancer in America, differences in attitudes and expectations can cause conflict and misunderstanding.

First truths, by G.W. von Leibniz.--Necessary and contingent truths, by G.W. Leibniz.--Of proposition, by T. Hobbes.--Introduction to the critique of pure reason, by I. Kant.--Kant, by A. Pap.--Of demonstration, and necessary truths, by J.S. Mill.--Views of some writers on the nature of arithmetical propositions, by G. Frege.--What is an empirical science, by B. Russell.--Two dogmas of empiricism, by W.V.O. Quine.--The meaning of a word, by J. Austin.--In defense of a dogma, by H.P. Grice and P.F. Strawson.

ABSTRACT Greek historical accounts of ancient eclipses were an important, if peculiar, focus of scientific attention in the nineteenth century. Victorian-era astronomers tried to correct the classical histories using scientific methods, then used those histories as data with which to calibrate their lunar theories, then rejected the histories as having any relevance at all. The specific dating of these eclipses—apparently a simple exercise in celestial mechanics—became bound up with tensions between scientific and humanistic approaches to the past as well as (...) with wider social debates over the power and authority of science in general. The major figures discussed here, including G. B. Airy, Simon Newcomb, and T. H. Huxley, argued that the critical question was whether science could speak authoritatively about the past. To them, the ability of science to talk about the past indicated its power to talk about the future; it was also the fulcrum of fierce boundary disputes among science, history, and religion. (shrink)

ABSTRACT Greek historical accounts of ancient eclipses were an important, if peculiar, focus of scientific attention in the nineteenth century. Victorian-era astronomers tried to correct the classical histories using scientific methods, then used those histories as data with which to calibrate their lunar theories, then rejected the histories as having any relevance at all. The specific dating of these eclipses—apparently a simple exercise in celestial mechanics—became bound up with tensions between scientific and humanistic approaches to the past as well as (...) with wider social debates over the power and authority of science in general. The major figures discussed here, including G. B. Airy, Simon Newcomb, and T. H. Huxley, argued that the critical question was whether science could speak authoritatively about the past. To them, the ability of science to talk about the past indicated its power to talk about the future; it was also the fulcrum of fierce boundary disputes among science, history, and religion. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:What Philosophy Can't Say About Literature:Stanley Cavell and EndgameBenjamin H. OgdenIn "Ending the Waiting Game," the philosopher of ordinary language Stanley Cavell attempts to say what Samuel Beckett's Endgame means by explaining what the characters in the play mean by what they say. Cavell attempts to do the very thing that the work says cannot be done, or mocks as foolish and misguided, or resists giving clues (...) to how it could ever be done: he tries to say just "how Beckett's objects mean at all, the original source of their conviction."1 This is not simply a reading tactic that Cavell thinks is well-suited to the difficult task of making sense of a difficult play. It is a demonstration of the theory of language (ordinary language philosophy) that Cavell defends and applies in his collection of essays Must We Mean What We Say?, of which "Ending the Waiting Game" is a chapter. Cavell's literary criticism is in the service of his philosophy. His work of criticism is in search of something that it must find (that is, something that it claims to have found even when it may not have); what it must find is a work of literature that demonstrates the utility and validity of ordinary language philosophy.If we are to take issue with Cavell for too strenuously transposing philosophy onto literature, then we must also know something of the philosophy he draws upon. Ordinary language philosophy traces its origins to Wittgenstein, and was popularized by J. L. Austin and Gilbert Ryle at Oxford in the 1940's. It is a branch of analytic philosophy that foregoes any attempt to create an "ideal philosophical language" of the sort Wittgenstein developed in his early Tractatus Logico-Philosophicus. Instead of seeing the abstractions and ambiguities of ordinary usage as something to be supplanted by a more logically rigorous system, ordinary language philosophers argue that debates over the meaning [End Page 126] of abstract terms come about precisely because words are removed from their ordinary context. For Cavell, the whole idea of an "ideal language" is absurd because, as anyone who has ever tried to learn a foreign language knows, every language has its own unique set of usages and idioms and unspoken rules. In order to speak a language properly, then, one cannot just know the dictionary or formal definitions of words (its "ideal" generative grammar), but must understand the "natural environment" in which phrases and words are logical or appropriate. Often these contexts (which determine the rules for "what we should say when" [p. 20]) invest words with meanings that you won't find in any dictionary, and cannot be catalogued in a grammatical or syntactical system.So, if one asks, "Did you dress that way voluntarily?" (p. 9), the word "voluntarily" takes on a meaning that is not included among its dictionary definitions (according to Cavell). Clearly, in asking whether you dress voluntarily one is not asking whether you have free-will to dress as you please, but is calling attention to the funny way you dress. In this case, successful communication is only possible if the one who is being questioned understands from context and the ordinary use of language precisely what is being asked. If he answers, "Of course I dressed voluntarily, I believe in free will," he will have misspoken, been incorrect. Clearly, he doesn't understand what the question must mean because the statement "MUST MEAN that my clothes are peculiar" (p. 9). For it to mean anything else would be a mistake and a misuse of language by the speaker, or a misunderstanding of language by the listener. To learn a language (which for Cavell means to become like a native speaker) is to learn the nature of the contingency between the explicit meaning of an expression and the occasion on which an expression is appropriate, and to be aware of what you must mean when you speak (what you cannot help but mean or imply by the language you use).What this means is that for Cavell reading literature becomes a process of readers "naturalizing ourselves to a new form of life, a new... (shrink)

T H McLaughlin; Parental Rights and the Religious Upbringing of Children, Journal of Philosophy of Education, Volume 18, Issue 1, 30 May 2006, Pages 75–83, http.

T H McLaughlin; Parental Rights and the Religious Upbringing of Children, Journal of Philosophy of Education, Volume 18, Issue 1, 30 May 2006, Pages 75–83, http.

T H McLaughlin; Religion, Upbringing and Liberal Values: a rejoinder to Eamonn Callan, Journal of Philosophy of Education, Volume 19, Issue 1, 30 May 2006, Page.

T H McLaughlin; Religion, Upbringing and Liberal Values: a rejoinder to Eamonn Callan, Journal of Philosophy of Education, Volume 19, Issue 1, 30 May 2006, Page.

T H Mclaughlin; Peter Gardner on Religious Upbringing and the Liberal Ideal of Religious Autonomy, Journal of Philosophy of Education, Volume 24, Issue 1, 30 Ma.

T H Mclaughlin; Peter Gardner on Religious Upbringing and the Liberal Ideal of Religious Autonomy, Journal of Philosophy of Education, Volume 24, Issue 1, 30 Ma.

To compare a novel to a work of philosophy is, admittedly, a risky exercise in analogy. When the novelist is Lawrence and the philosophical text is the ponderous and dialectical Being and Nothingness, such a comparison may seem willfully perverse and peculiarly open, insofar as it deals with Lawrence's great theme of sexuality, to his anathema of "sex in the head." Furthermore, modern criticism, especially in the Anglo-Saxon world, has tended to be wary of critical approaches that lean on notions (...) that are not derived from literature itself - a tendency that is being reinforced these days by the structuralist insistence on the "literariness" of the Text. Now, despite its metaphorical statement as a form of dramatic "gesture," Sartre's book is very definitely not a work of literature. T.H. Adamowski, associate professor of English at Erindale College, the University of Toronto, has written articles on English, American, and French literature. This essay is part of a larger study on progress on Lawrence's "sexual poetics.". (shrink)

Both Plato and Aristotle have something to say about admiration. But in order to know where to look, and in order to appreciate the force of their remarks, we need to sketch a little of the ethical background that they presuppose. I begin, therefore, with ancient Greek ethics in the wider sense, and discuss the treatment of admiration and related attitudes by Homer, Herodotus, and other pre-Platonic sources. Then I turn to the views of Plato, Adam Smith, Aristotle and Cicero. (...) This order of discussion allows us to see why admiration is both morally significant and, in some respects, morally unreliable. (shrink)

Students of the history of ethics sometimes find themselves tempted by moderate or extreme versions of an approach that might roughly be called ‘historicist’. This temptation may result from the difficulties of approaching historical texts from a ‘narrowly philosophical’ point of view. We may begin, for instance, by wanting to know what Aristotle has to say about ‘the problems of ethics’, so that we can compare his views with those of Aquinas, Hume, Kant, Sidgwick, and Rawls, and then decide what (...) is true or false in each theorist's position. But this narrowly philosophical attitude soon runs into difficulties, and writers on the history of ethics often warn us against it. (shrink)

Hanshan, which means Cold Mountain, was the pseudonym adopted by an unknown poet who lived in China as a hermit twelve hundred years ago. The poems collected under his name have had an immense impact worldwide, especially among Zen Buddhists, and have been translated into many languages. Peter Hobson's translation of more than a hundred of the poems, almost all of which are published for the first time in this volume, brings those qualities of timelessness, poetic diction and engaging rhythm (...) that do justice to the concepts and language of the original. This edition includes not only a clear and succinct introduction for the general reader but also highly informative sections on Hanshan's place in history and on issues involved in translating Hanshan. (shrink)